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Effect of COX-2 inhibition on CMMCs in obstructed colon. A and B: electrical recording of CMMC in obstructed colon before and after valdecoxib (10 μM), where CMMC is preceded by a hyperpolarization. C and D: valdecoxib (10 μM) increases transit of a fecal pellet (C) and causes propagation of CMMCs in obstructed colon (D).
