Table 2.
Phenotypic analysis of CD4+ T cells and subsets from PD patients compared to caregivers in Cohort B
| Population | Population Subset | Caregivers | PD patients | p-values | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Mean ± SEM (%) | Median (%) | Range (%) | n | Mean ± SEM (%) | Median (%) | Range (%) | Mann–Whitney | Benjamini-Hochberg | ||
| CD4+ T cells | CD45RO+ | 62 | 64.4 ± 1.5 | 65.2 | 37.6–93.4 | 71 | 69.6 ± 1.5 | 69.7 | 22.4–91.4 | 0.009 | 0.028 |
| CD45RA+ | 62 | 27.5 ± 1.4 | 27.8 | 3.0–54.0 | 71 | 22.4 ± 1.5 | 21.4 | 2.1–72.8 | 0.004 | 0.028 | |
| FAS+ | 65 | 60.0 ± 1.8 | 61.2 | 27.7–96.1 | 72 | 67.0 ± 1.7 | 67.6 | 22.4–93.3 | 0.006 | 0.028 | |
| CD31+ | 65 | 28.8 ± 0.9 | 28.1 | 14.7–47.3 | 72 | 25.3 ± 0.9 | 25.6 | 10.6–41.2 | 0.014 | 0.031 | |
| Integrin α4β7+ | 53 | 37.6 ± 1.5 | 36.6 | 20.8–60.0 | 58 | 31.8 ± 1.3 | 33.3 | 12.0–55.6 | 0.021 | 0.034 | |
| Integrin α4β1+ | 41 | 52.5 ± 1.5 | 50.7 | 38.2–78.2 | 47 | 55.6 ± 1.6 | 54.5 | 34.4–82.0 | 0.08 | 0.10 | |
| CD25+ | 64 | 13.2 ± 0.4 | 13.0 | 6.8–21.1 | 71 | 13.7 ± 0.4 | 13.3 | 7.1–20.8 | 0.48 | 0.54 | |
| CD127+ | 64 | 63.7 ± 0.8 | 64.0 | 44.0–77.0 | 71 | 64.2 ± 0.8 | 64.7 | 44.9–79.6 | 0.66 | 0.66 | |
| CD4+CD25+ CD127+ Teff | CD45RO+ | 60 | 88.1 ± 0.8 | 89.9 | 69.4–97.6 | 70 | 89.2 ± 0.9 | 91.6 | 57.0–98.4 | 0.07 | 0.08 |
| CD45RA+ | 60 | 5.2 ± 0.6 | 3.7 | 0.2–20.4 | 70 | 4.6 ± 0.7 | 2.8 | 0.2–33.9 | 0.05 | 0.06 | |
| FAS+ | 63 | 89.9 ± 1.3 | 92.2 | 35.4–99.3 | 71 | 92.7 ± 0.8 | 95.0 | 60.9–98.8 | 0.04 | 0.06 | |