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. Author manuscript; available in PMC: 2012 Dec 5.
Published in final edited form as: Pflugers Arch. 2007 Nov 15;455(5):787–797. doi: 10.1007/s00424-007-0385-1

Figure 2. Rho-linked mental retardation proteins and effector pathways connecting Rho GTPases to actin dynamics.

Figure 2

Proteins encoded by Rho-linked genes involved in different forms of MR are highlighted in red text. See main text for explanation. Abbreviations: ARHGEF6, a Rho guanine nucleotide exchange factor 6; Arp2/3, actin-related proteins 2 and 3; Aß, amyloid ß; CREB, cAMP-responsive element-binding protein; CYFIP, cytoplasmic FMR1 interacting protein; LIM, Lin-11, Isl-1 and Mec-3 kinase; MEGAP, MEntal disorder-associated GAP protein; MLC, myosin light chain; MLCK, myosin light chain kinase; MLCP, myosin light chain phosphatase; OPHN1, oligophrenin-1; PAK, p21-activated kinases; WASP, Wiskott-Aldrich-syndrome protein; WAVE, WASP family Verprolin-homologous protein.