Figure 4.
Methylation status of IC at 15q11. Box plots of methylation values quantified as %5-methylated cytosines (%5-mC) with pyrosequencing analysis in 12 TC2 samples and 18 MM of other TC groups, 4 paired controls (purified peripheral T cells) of TC2 samples and 4 normal controls. Imprinted normal locus presents 50% methylation, with respect to which both TC2 and not-TC2 MM are significantly hypomethylated (Wilcoxon rank-sum tests' P-values are reported).
