TABLE 1.
Conservation of the selected histidines in the RVFV Gn and Gc glycoproteins among members of the Phlebovirus genus of the Bunyaviridae family as determined by ClustalW alignment
| Phlebovirus (GenBank accession no.) | Amino acid at indicated positiona in: |
|||||||
|---|---|---|---|---|---|---|---|---|
| Gn protein |
Gc protein |
|||||||
| 157 | 540 | 572 | 580 | 778 | 836 | 857 | 1087 | |
| Rift Valley fever virus (JF784387) | H | H | H | H | H | H | H | H |
| Sandfly fever Naples virus (YP089671) | H | H | H | H | H | H | H | H |
| Toscana virus (ABS85173) | H | H | H | H | H | H | H | H |
| Massilia virus (ACI24011) | H | H | H | H | H | H | H | H |
| Echarate virus (HM119411) | H | Y | Y | H | H | H | H | H |
| Turuna virus (HM119432) | H | H | N | H | H | H | H | H |
| Chandiru virus (HM119408) | H | H | N | H | H | H | H | H |
| Mucura virus (HM119420) | H | H | Q | H | H | H | H | H |
| Ariquemes virus (HM119405) | H | H | S | H | H | H | H | H |
| Morumbi virus (HM119423) | H | H | T | H | H | H | H | H |
| Alenquer virus (HM119402) | H | H | K | H | H | H | H | H |
| Itaituba virus (HM119417) | H | H | K | H | H | H | H | H |
| Serra Norte virus (HM119429) | H | Y | K | H | H | H | H | H |
| Nique virus (HM119426) | H | H | N | H | H | H | H | H |
| Oriximina virus (HM119435) | H | Y | H | H | H | H | H | H |
| Jacunda virus (HM466935) | H | Y | Y | H | H | H | H | H |
| Sandfly fever Sicilian virus (AAA75043) | H | H | E | H | R | H | H | H |
| Punta Toro virus (ABD92923) | H | H | H | H | H | H | H | H |
| Severe fever with thrombocytopenia syndrome virus (HM745931) | — | H | E | Y | R | R | P | S |
| Uukuniemi virus (AAA79512) | — | R | A | F | H | R | Y | H |
Amino acid numbers correspond to the RVFV M-segment encoding polyprotein. —, ClustalW alignment displays a gap at this position.