Figure 5.
Quantitative analysis of intracellular superoxide anion (A) and western blot analysis of gp91phox protein expression (B) in aortas of wild-type littermates and Tg2576 mice without (−) or with (+) GW501516 treatment. Results are means ± SEM (n = 6–9 for superoxide anion and n = 4–5 for gp91phox). Effect of NADPH oxidase inhibition with VAS-2870 on superoxide anion levels in wild-type and Tg2576 mice aortas (C). *P < 0.05 vs. wild-type mice; **P < 0.05 vs. transgenic T2576 mice; ***P < 0.05 vs. control aortas (two-way ANOVA).