Figure 8. Pharmacokinetic profiles of mAb variants in Harlan athymic nude mice. The two groups conducted in this study were mAb2 with > 99% Man5 (solid black circle) and mAb2 with > 99% Man8/9 (solid gray triangle). The complex-fucosylated profile (open squares) was from a separate study conducted in a similar fashion to the current study. Mice were injected with single I.V. dose of 10 mg/kg mAbs with specific glycoform, and serum samples were collected in the indicated time points up to 28 d. Triplicate sample set was collected for each time point. Average values are reported and the error bars represent standard deviation. The data was fit to a 2 compartment model for the calculation of pharmacokinetic parameters illustrated in Table 1.