Table III.
Literature review for the 19 significant GWAS candidate genes in suicides (based on OMIM database*).
| Gene symbol | Chro.# | Description | Suggested clinical role* | Similar genes found by others in expression studies |
|---|---|---|---|---|
| CDH13 | 16 | Cadherin 13, H-cadherin (heart) | Lung tumour recurrence? | CDH12, CDH22 (Thalmeier et al. 2008) |
| NPR3 | 5 | Natriuretic peptide receptor C | Maintenance of blood pressure | |
| CD300LB | 17 | CD300 antigen-like family member b | Cell surface localization in B and NK cells | |
| FOXN3 | 14 | Forkhead helix transcription | DNA damage correction? | ADAMTS1, IGF1, VIP, WDR39 (Thalmeier et al. 2008) |
| DISC1 | 1 | Disrupted in schizophrenia 1 | Susceptibility for schizophrenia (Millar et al. 2000) | |
| CYP19A1 | 15 | Cytochrome P450, family 19, subfamily A, polypeptide 1 | Aromatase deficiency | |
| MYO3A | 10 | Myosin IIIA | Autosomal recessive deafness | MYR8 (Thalmeier et al. 2008) |
| SFRS11 | 1 | Arginine/serine-rich 11 splicing factors | Pre-mRNA splicing? | |
| LSAMP | 3 | Limbic system-associated membrane protein | Neuronal surface glycoprotein in limbic system (Pimenta et al. 1996) | |
| DSC2 | 18 | Desmocollin 2 | Ca-dependent glycoprotein important for cell adhesion | |
| SPTLC1 | 9 | Serine palmitoyltransferase, long chain base subunit 1 | Hereditary sensory neuropathy | |
| ACCN1 | 17 | Amiloride-sensitive cation channel 1, neuronal (degenerin) | Neurodegeneration? KO-mice reduced sensitivity to mechanic sensation | |
| FLJ23312 | 5 | Hypothetical protein | Not known | FLJ21616 (Sequeira et al. 2007) |
| MBNL2 | 13 | Muscleblind-like 2 | May be associated with myotonic dystrophy | |
| CD44 | 11 | CD44 molecule | Migration, cell fusion, tumorgenesis? | (Thalmeier et al. 2008; Sequira et al. 2007) |
| TUBGCP3 | 13 | Tubulin, gamma complex associated protein 3 | Associated with gama-tubulin in cells and oocytes | |
| KBTBD2 | 7 | Kelch repeat and BTB (POZ) | Not known in humans | |
| COL14A1 | 8 | Collagen, type XIV, alpha 1 (undulin) | Not known in humans | |
| MARCH1 | 4 | Membrane-associated RING-CH protein I | Down-regulation of histocompatibility complex |
GWAS, genome wide association study.
*
OMIM, Online Mendelian Inheritance in Man.