Table 2.
Plasma lipid profile of SFA mice switched to diets + drug for 8 weeks
| |
|
|
SFA 12wk |
|||||
|---|---|---|---|---|---|---|---|---|
| |
↓ |
|
||||||
| LF 20wk | SFA 20wk | LF + At 8wk | SFA + At 8wk | LF + Pr 8wk | SFA + Pr 8wk | LF + Ib 8wk | SFA + Ib 8wk | |
|
Cholesterol (mM) |
1.64 ± 0.14 |
1.43 ± 0.08 |
1.17 ± 0.11a |
1.55 ± 0.14 |
1.52 ± 0.17 |
1.37 ± 0.09 |
1.81 ± 0.26 |
1.19 ± 0.11a |
|
Triglycerides (mM) |
0.80 ± 0.12 |
0.55 ± 0.14 |
0.40 ± 0.04a |
0.63 ± 0.09 |
0.89 ± 0.09b |
1.00 ± 0.17b |
0.57 ± 0.07 |
0.80 ± 0.14 |
| NEFA (mEq/L) | 0.70 ± 0.04 | 0.61 ± 0.07 | 0.50 ± 0.07a | 0.62 ± 0.05 | 0.62 ± 0.06 | 0.51 ± 0.04a | 0.52 ± 0.04a | 0.52 ± 0.06a |
The table shows the effects of various feeding regimens on plasma lipids. Plasma total cholesterol, triglycerides and non-esterified fatty acids (NEFA) were measured at the end of the feeding regimen. Data represented as mean ± standard error of mean. Means were compared with non-parametric independent t test, where P < 0.05 considered statistically significant.
a: statistically significant in comparison to LF.
b: statistically significant in comparison to SFA.
Abbreviations: LF, low-fat; SFA, saturated fatty acids; At, atorvastatin; Pr, pravastatin; Ib, ibuprofen; wk, weeks.