Table 4.
Determinants of vascular measurements (FMD, NMD and PWV) in multivariate analysis
|
Multivariate analysis |
|||
|---|---|---|---|
| B (95% CI) | P | ||
| FMD, % |
Time since diagnosis of diabetes, years* |
−0.40 (−0.66, -0.14) |
0.003 |
| NMD, % |
Age, years* |
−5.66 (−9.49, -1.82) |
0.004 |
| Hypertension |
−1.80 (−3.25, -0.35) |
0.015 |
|
| Fasting glucose, μmol/L |
−0.36 (−0.54, -0.18) |
0.005 |
|
| PWV, m/sec | Age, years* |
6.22 (3.81, 8.63) |
<0.001 |
| Systolic blood pressure, mmHg | 0.03 (0.00, 0.05) | 0.032 | |
*Natural logarithm transformed variables. FMD, flow-mediated dilation of the brachial artery; NMD, nitrate-mediated dilation of the brachial artery; PWV, carotid-femoral pulse wave velocity.
The independent variables included in the stepwise model were parameters whose association with the vascular parameters achieved statistical significance (P < 0.05) and other factors that may affect endothelial dysfunction and arterial stiffness (age, gender, heart rate, systolic blood pressure and use of antihypertensive medications).