Table 7.
Comparison of Patients With Occluded (TIMI 0/1) and Patent (TIMI 2/3) Culprit Arteries at Presentation: Estimated Effects on CMR Parameters Associated With a 20% Increase in IMR (mm Hg/s)
| Patients With an Occluded Culprit Artery(n=70) | Patients With a Patent Culprit Artery(n=38) | |||
|---|---|---|---|---|
| IMR Effect (95% CI) | P | IMR Effect (95% CI) | P | |
| Multivariable associations,* early CMR (2 days) | ||||
| Infarct size, % | 1.56 (0.69 to 2.43) | <0.001 | 1.97 (0.94 to 2.99) | <0.001 |
| Myocardial salvage index, % | −3.68 (−5.26 to −2.11) | <0.001 | −3.10 (−5.88 to −0.32) | 0.034 |
| Microvascular obstruction, % | 0.26 (0.01 to 0.51) | 0.041 | 0.11 (−0.09 to 0.31) | 0.270 |
| Hemorrhage, % | 0.28 (0.13 to 0.44) | <0.001 | 0.15 (0.01 to 0.28) | 0.043 |
| Left ventricular ejection fraction, % | −0.72 (−1.38 to −0.07) | 0.032 | −0.65 (−1.57 to 0.27) | 0.168 |
| Multivariable associations,† late CMR (3 months) | ||||
| Infarct size, % | 0.27 (−0.12 to 0.67) | 0.176 | −0.36 (−1.10 to 0.38) | 0.344 |
| Myocardial salvage index, % | −1.11 (−2.34 to 0.12) | 0.079 | 1.09 (−1.03 to 3.21) | 0.318 |
| Left ventricular ejection fraction, % | −0.32 (−0.77 to 0.14) | 0.173 | 0.14 (−0.50 to 0.78) | 0.663 |
Results are additive effects on the CMR parameters. Results at 3 months are adjusted for the initial value of the outcome being analyzed.
For all baseline CMR outcomes, adjustment was made for the following variables: previous MI, sex, pain‐to‐balloon time, door‐to‐balloon time, thrombectomy, catheterization laboratory pulse pressure, TIMI flow, corrected TIMI frame count, and percent of ST elevation still present after PCI.
For all follow‐up CMR outcomes, we adjusted for baseline value of the CMR parameter, age, door‐to‐balloon time, glycoprotein IIb/IIIa, TIMI flow, and percent of ST elevation still present after PCI.