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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: J Neurochem. 2012 Nov;123(Suppl 2):108–115. doi: 10.1111/j.1471-4159.2012.07949.x

Figure 4. SAHA preserves CFP (+) expression in MONs from older mice.

Figure 4

(a) CFP (+) mitochondria were longer and thicker in MONs from 12 month old Thy-1 CFP mice (inset; scale bar = 2 μm). OGD consistently reduced CFP pixel intensity in 12 month old MONs despite longer and brighter CFP (+) mitochondria (yellow arrows). (b) Blockade of AMPA/kainate receptors with NBQX (30μM), or pan-HDAC inhibition with SAHA (5μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery. * p<0.05, **p<0.001, *** p<0.0001, one-way ANOVA. Scale bar = 10 μm.