Figure 2. Crystal Structures of Tat Transcription Complexes.

(A) Crystal structure of the HIV-1 Tat/CDK9/CycT1 complex (PDB accession code 3MIA) (Tahirov et al., 2010). The two zinc-finger assemblies are shown as stick representations. The position of the catalytic phospho-Thr186 in the T-loop of CDK9 is indicated. (B) Crystal structure of the EIAV Tat/TAR/CycT1 complex (2W2H) (Anand et al., 2008). The N- and C-terminal regions of Tat merge at the position of a tyrosine residue in the core region of Tat.