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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Nat Genet. 2012 Sep 2;44(10):1126–1130. doi: 10.1038/ng.2387

Figure 2.

Figure 2

LIN28B risk alleles correlate with increased LIN28B expression and decreased let-7 miRNA expression. (a) LIN28B mRNA expression is significantly higher in neuroblastoma cell lines homozygous for the rs17065417 risk allele (AA) compared to neuroblastoma cell lines heterozygous for the risk allele (CA). Given the MAF of rs17065417, we did not identify any cell lines homozygous for the protective allele (CC). (b) Neuroblastoma cell lines homozygous for the rs17065417 risk allele show high expression of MYCN. (c) Western blot confirms increased protein expression of LIN28B in neuroblastoma cell lines homozygous for the rs17065417 risk allele. (d) Neuroblastoma cell lines homozygous for the rs17065417 risk allele and with high LIN28B expression show decreased or absent expression of the let-7 miRNAs.