Abstract
Screening of Aspergillus funiculosus for bioactive secondary metabolites produced kojic acid, which is know to have wide range of biological properties. It is very active against Gram-negative bacteria, such as Pseudomonas aeruginosa and Escherichia coli, but moderately active against yeasts and Gram-positive bacteria except Staphylococcus epidermidis. Filamentous Fungi are more sensitive to kojic acid. When it exposed to larvicidal activity on Aedes aegypti third instar larvae are more sensitive than early fourth instar larvae.
Keywords: Aspergillus funiculosus, Secondary metabolites, Kojic acid, Antibacterial, Aedes aegypti, Larvicidal
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References
- 1.Pelaez F. The historical delivery of antibiotics from microbial natural products—Can history repeat? Biochemical Pharmacology. 2006;71–7:981–990. doi: 10.1016/j.bcp.2005.10.010. [DOI] [PubMed] [Google Scholar]
- 2.Berdy J. Screening, classification and identification of microbial products. In: Verral M.S., editor. Discovery and Isolation of Microbial Products. Chichester: Ellis Horwood; 1985. pp. 9–31. [Google Scholar]
- 3.Berdy J (1988) New trends in the research of bioactive microbialmetabolites. In Chemistry and Biotechnology of Biologically Active Natural Products, 4th Int. Conf., Budapest, 1987, pp. 269–291
- 4.Berdy J. Bioactive Microbial Metabolites. A Personal View. J Antibiot. 2005;58(1):1–26. doi: 10.1038/ja.2005.1. [DOI] [PubMed] [Google Scholar]
- 5.Demain A. Pharmaceutically active secondary metabolites of microorganisms. Appl Microbiol Biotechnol. 1999;52:455–463. doi: 10.1007/s002530051546. [DOI] [PubMed] [Google Scholar]
- 6.Grabley S., Thiericke R. The impact of natural products on drug discovery. In: Grabley S., Thiericke R., editors. Drug discovery from nature. New York Berlin Heidelberg: Springer; 1999. pp. 3–37. [Google Scholar]
- 7.Ciegler A., Peterson R.E.A., Lagoda A., Hall H.H. Aflatoxin production and degradation by Aspergillus flavus in 20-liter fermentors. Appl Microbiol. 1966;14:826–833. doi: 10.1128/am.14.5.826-833.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Linday M.E. Practical Introduction to Microbiology. United Kingdom: E and F.N. Spon Ltd.; 1962. p. 177. [Google Scholar]
- 9.Perez C., Paul M., Bazerque P. An Antibiotic assay by the agar well diffusion method. Acta Bio Med Exp. 1990;15:113–115. [Google Scholar]
- 10.Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard. 6th edition. Wayne, PA: NCCLS; 2003. [Google Scholar]
- 11.World Health Organization (1981) Instructions for determining susceptibility or resistance of mosquito larvae to insecticides. WHO/VBC-81, pp. 807
