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. 2012 Jun 18;40(16):8155–8162. doi: 10.1093/nar/gks557

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — The three C-C pairs: from the native duplex A + B (A, D, G) and the LNA-containing duplexes C + D (B, E, H) and E + E′ (C, F, I). The first row shows the possible H-bonds. The second row shows the Van der Waals interactions, especially the close proximity of the exo-amine groups. The third row shows the propeller twist of the bases.