Table 2.
Regions of interest showing differences in functional connectivity (typically developing > autism spectrum disorders)
| Regions of interest in matrix row/column order | Talairach coordinates of region of interest ‘peak’ |
Volume (mm3) | Regions of interest with seed | Overlapping seed maps (max) | ||
|---|---|---|---|---|---|---|
| X | Y | Z | ||||
| 1 Ventromedial prefrontal | 3 | 27 | −16 | 3864 | 17 | 1 |
| 2 Left amygdala | −23 | −5 | −16 | 1032 | 1 | 1 |
| 3 Left hippocampus | −31 | −19 | −12 | 1048 | 11 | 1 |
| 4 Right ventromedial anterior temporal | 21 | 1 | −36 | 1448 | 14 | 1 |
| 5 Left ventromedial anterior temporal | −23 | 5 | −38 | 1424 | 9 | 0 |
| 6 Right anterior middle temporal gyrus/superior temporal gyrus | 53 | −5 | −16 | 1792 | 6 | 2 |
| 7 Right dorsomedial frontal pole | 9 | 61 | 16 | 376 | 2 | |
| 8 Left inferior frontal gyrus (pars triangularis) | −43 | 17 | 20 | 424 | 3 | |
| 9 Left inferior frontal gyrus (pars orbitalis) | −41 | 31 | 2 | 800 | 3 | |
| 10 Left inferior frontal gyrus (pars opercularis) | −41 | 15 | −2 | 544 | 3 | |
| 11 Right inferior frontal gyrus (pars opercularis) | 53 | 13 | −6 | 496 | 2 | |
| 12 Left inferior temporal gyrus | −59 | −37 | −8 | 2208 | 1 | 2 |
| 13 Left temporo-parietal junction | −47 | −59 | 12 | 2016 | 2 | 3 |
| 14 Left anterior superior temporal | −53 | 9 | −6 | 5424 | 4 | |
| 15 Right superior temporal sulcus | 55 | −45 | 6 | 2280 | 5 | |
| 16 Left anterior superior frontal | −23 | 41 | 24 | 1360 | 3 | |
| 17 Left occipital | −9 | −83 | 36 | 6176 | 3 | |
| 18 Left cuneus | −3 | −93 | 12 | 232 | 2 | |
| 19 Right precuneus | 15 | −63 | 54 | 2736 | 3 | |
| 20 Left fusiform gyrus | −45 | −45 | −18 | 744 | 2 | |
| 21 Right posterior middle temporal gyrus/occipital | 49 | −73 | −2 | 10 208 | 10 | 6 |
| 22 Right dorsal occipital | 23 | −75 | 28 | 3280 | 4 | |
| 23 Left postcentral gyrus | −45 | −31 | 58 | 4408 | 2 | 4 |
| 24 Right postcentral gyrus | 21 | −27 | 68 | 2128 | 3 | 2 |
| 25 Left supplementary motor area | −3 | −3 | 64 | 208 | 2 | |
| 26 Right supplementary motor area | 5 | −9 | 64 | 296 | 2 | |
| 27 Left cerebellum | −35 | −59 | -48 | 1856 | 13 | 0 |
Regions of interest are listed in order of their row/column presentation in Figs. 4 and 5, where r Regions 1–7 are members of Cluster 1 (red), Regions 8–16 are members of Cluster 2 (blue), and Regions 17–27 are members of Cluster 3 (green). Bold text indicates that a region of interest was one of the 12 seed regions of interest that produced significant (corrected) results. Peak Talairach coordinates are for the peak t-value in seed regions of interest for the group comparisons of functional connectedness (Fig. 2), and for the spatial centroid of non-seed regions of interest. The rightmost two columns show: (i) the total number of regions of interest (out of 27) containing at least one voxel in the corrected t-test maps for each seed; and (ii) the maximum overlap of the corrected t-test maps for each seed (out of 12) in any single voxel within the region of interest (Supplementary Fig. 4).