Table 1.
Activation levels of SEAP expression in cancer cells infected with RD Ad TetON–SEAP or coinfected with TetON–SEAP and RC Ad KD3 or KD3–IFN (fold increase)
| Dox |
TetON–SEAP
|
TetON–SEAP +KD3
|
TetON–SEAP +KD3–IFN
|
|||
|---|---|---|---|---|---|---|
| − | + | − | + | − | + | |
| A549 | 1 | 4.7±0.4 | 14.1±7.9 | 82.4±18.5 | 13.8±7.6 | 59.3±8.6 |
| Hep3B | 1 | 4.5±0.7 | 39.5±23.4 | 231.9±48.7 | 37.5±58.0 | 205.1±54.4 |
| DLD-1 | 1 | 1.7±0.1 | 3.2±1.1 | 47.2±4.2 | 5.7±0.9 | 63.8±3.8 |
| 293 | 1 | 23.7±1.7a | ND | ND | ND | ND |
Abbreviation: ND, not determined; IFN, interferon; RC, replication competent; SEAP, secreted placental alkaline phosphatase.
a
TetON–SEAP replicates in 293 cells.