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. 2012 Sep 4;7(9):e44667. doi: 10.1371/journal.pone.0044667

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© 2012 Holmuhamedov et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, Dose-dependent effect of diazoxide on restoration of Ca²⁺-inhibited State 3 respiration in subsarcolemmal (SSM) (triangles) and interfibrillar (IFM) (circles) mitochondria. B, Effect of diazoxide on Ca²⁺-inhibited State 3 respiration in SSM and IFM preloaded with (0–150 nmol Ca²⁺/mg protein). C, Bar graphs of diazoxide (100 µM)-mediated recovery of Ca²⁺-inhibited State 3 respiration in SSM and IFM loaded with 150 (open bars) and 30 nmol Ca²⁺/mg protein (hatched bars), n = 3. Asterisks signify statistical differences with p<0.05.