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. 2012 Sep 4;7(9):e44667. doi: 10.1371/journal.pone.0044667

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© 2012 Holmuhamedov et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, Depolarizing effect of diazoxide (100 µM) in SSM (open bar) and IFM (filled bar), n = 6, p<0.05. B, Mitochondrial Ca²⁺ uptake in SSM and IFM in the absence (-DZ) and presence (+DZ) of diazoxide (100 µM). C, Inhibition of the rate of Ca²⁺ uptake in SSM (open bar) and IFM (filled bar), n = 6, p<0.05. D, Diazoxide (100 µM) mediated Ca²⁺ release from preloaded SSM and IFM. E, Average rate of diazoxide-mediated Ca²⁺ release from mitochondria, n = 3, p<0.05. F and G, Dose-dependent effect of diazoxide on Ca²⁺ uptake (F) and Ca²⁺ release (G) in SSM (triangles) and IFM (circles), n = 6.