. 2012 Aug 1;32(31):10541–10553. doi: 10.1523/JNEUROSCI.0767-12.2012

Table 1.

Clinical features of patient cohort

Case	Age (years)/sex	Disease duration (years)	Predominant symptoms (in addition to akinesia)	Preoperative medication (total daily dose)	UPDRS ON/OFF medication	UPDRS OFF medication/ON DBS	Remarks
1	40/male	10	Gait impairment, tremor	1200 mg of levodopa, 5 mg of pramipexole	9/30	21	Additional tics from age 12
2	55/male	15	Tremor, freezing, motor fluctuations	1000 mg of levodopa, 16 mg of ropinirole, 10 mg of selegiline, 100 mg of amantadine	5/19	18
3	59/female	13	Gait freezing, dyskinesias	500 mg of levodopa, 1 mg of cabergoline, 100 mg of amantadine, 2 mg of apomorphine	10/36	11	Recording done ON medication only; cluster headache
4	45/female	8	Tremor	27 mg of ropinirole	–/50	42	DBS lead only in the right STN; the patient was intolerant of levodopa so recording done OFF medication only
5	58/female	14	Gait freezing, pain, dyskinesias, motor fluctuations	250 mg of levodopa, 4 mg of pramipexole	18/71	15^b
6	64/female	8	Tremor, dyskinesias	500 mg of levodopa, 17 mg of ropinirole, 300 mg of amantadine, 1 mg of rasagline	18/51	23^a	Recording done ON medication only; hypothyroidism
7	51/male	9	Gait impairment, tremor	800 mg of levodopa, 1 mg of rasagiline	21/49	19^c	REM sleep disorder; previous DOPA dysregulation
8	60/male	15	Dyskinesias, gait freezing, tremor	1300 mg of levodopa, 18 mg of ropinirole, 10 mg of selegiline, 2 mg of amantadine	10/56	23
9	54/male	8	Gait impairment, dyskinesias	1200 mg of levodopa, 4 mg of cabergoline, 800 mg of entacapone, 300 mg of amantadine	9/38	15^a
10	66/male	8	Freezing, motor fluctuations, dyskinesias, tremor	800 mg of levodopa, 2 mg of pramipexole, 1 mg of rasagline, 200 mg of amantadine, 4–8 mg of apomorphine	18/72	21^a	Recording done ON medication only
11	48/male	11	Gait freezing, tremor	1250 mg of levodopa, 1 mg of rasagiline, 500 mg of entacapone	16/72	25^c
12	63/female	9	Tremor, pain	4 mg of rotigotine, 1 mg of rasagiline	–/51	12^d	LRRK2 mutation; patient was intolerant to levodopa, so recording was done OFF medication only
13	61/male	9	Gait freezing, tremor	1800 mg of levodopa, 500 μg of pramipexole	5/28	19
14	58/female	10	Dystonia, dyskinesia, motor fluctuations	450 mg of levodopa, 3 mg of pramipexole, 2 mg of rasagiline	16/55	16^c
15	52/male	12	Dystonia	950 mg of levodopa, 4 mg of rotigotine, 1 mg of rasagiline	10/35	26
16	58/male	13	Gait freezing	1200 mg of levodopa, 400 mg of amantadine, 600 mg of entacapone, 1 mg of rasagiline	25/43	17
17	57/male	17	Gait impairment, pain, dyskinesias	1550 mg of levodopa, 1600 mg of entacapone, 10 mg of selegiline, 200 mg of amantadine	14/54	32

All patients received bilateral STN DBS electrodes except for case 4. The dose of pramipexole is given as a salt. Psychiatric comorbidities were mania and compulsivity (1 case), hypersexuality (2 cases), depression (1 case), past history of gambling on dopamine agonist (1 case). UPDRS scores OFF medication/ON DBS were assessed at 6 months (a), 8 months (b), 10 months (c), or 1 year (unmarked) post-operatively. Subject 12 was assessed on 1 mg of rasagiline ON DBS (d).