Figure 4. Smoking alters expression of Flt1 in alveolar macrophages.
(A) Flt1 expression data from the mRNA array. Shown are normalized log values for the study subjects. (B) Flt1 variants image from University of California Santa Cruz (Santa Cruz, CA, USA) Human (Homo sapiens) Genome Browser Gateway (http://genome.ucsc.edu/cgi-bin/hgGateway). (C) Analysis of Flt1 variant expression in a nonredundant set of eight never smokers and eight active smokers. Primers for quantitative RT-PCR were chosen from unique 3′ sequences in each of the variants (var1–3). (D) Data from quantitative RT-PCR in C, shown as a ratio between variant 2 and variant 1 (upper) or variant 3 and variant 1 (lower).