Figure 1. Specialized pro-resolving mediators (SPM) in obese adipose tissue: LC-MS/MS-based lipid mediator metabolo-lipidomics.
(A) MRM chromatograms (m/z 375>233, 375>215 and 359>153) and representative tandem mass spectra of resolvin D1 (RvD1) (B), RvD2 (C) and protectin D1 (PD1) (D) in adipose tissue from obese mice. (E) Quantitation of SPM in adipose tissue from lean and obese mice. (F) Quantitation of monohydroxy markers of RvE1 and RvD1 biosynthetic pathways from EPA and DHA in adipose tissue from lean and obese mice. Results represent the mean±SEM of 5 different individuals.
