Fig 9.
DSS compounds do not inhibit DHBV polymerase activity. DHBV virion particles derived from the sera of congenitally DHBV-infected ducks were subjected to an endogenous polymerase reaction with [32P]dCTP plus CCC-0975 or CCC-0346 at 10 μM. DMSO at 0.1% was used as a solvent control. PFA served as a positive control for polymerase inhibitor. Incorporated [32P]dCTP radioactivity was measured with a liquid scintillation counter. Relative polymerase activity was plotted as a percentage of the counts per minute read in the control reaction mixture (y axis). Values are averages of triplicate samples, and error bars represent standard deviations.