Table 1.
Mean histopathology score at end-of-life
| Ercc1+/+ | Ercc1−/Δ7 | ||||
|---|---|---|---|---|---|
| Mean | 95% CI | Mean | 95% CI | p-Valuea | |
| Liver anisokaryosis | 3.8 | (3.3–4.3) | 4.1 | (3.8–4.3) | ns |
| Liver intranuclear inclusions | 2.3 | (1.7–2.9) | 4.1 | (3.8–4.3) | <0.0001 |
| Liver lipofuscin | 2.8 | (2.3–3.3) | 2.2 | (2.0–2.4) | 0.036 |
| Kidney anisokaryosis | 1.1 | (0.3–1.8) | 4.2 | (4.0–4.4) | <0.0001 |
| Kidney tubular degeneration | 2.8 | (2.2–3.3) | 2.0 | (1.7–2.4) | 0.043 |
| Heart myocardial degeneration | 1.9 | (1.2–2.7) | 2.0 | (1.6–2.3) | ns |
| Brain vacuolization | 3.0 | (2.3–3.7) | 1.8 | (1.3–2.4) | 0.014 |
| Spinal cord vacuolization | 3.1 | (2.5–3.7) | 2.2 | (1.7–2.7) | 0.032 |
| Peripheral nerve vacuolization | 2.8 | (2.6–3.6) | 2.9 | (2.3–3.6) | ns |
| Femur bone marrow fatty infiltrationb | 1.2 | (0.5–2.0) | 3.3 | (2.8–3.8) | 0.0002 |
| Testis tubular degeneration | 2.2 | (1.5–2.9) | 4.7 | (4.3–5.2) | 0.0002 |
Note: End-of-life: moribund mice from life span cohorts. Combined results of male and female mice based on 10–35 mice per group, except for testis for which 10 and 7 males were analyzed per group.
ns, not significant.
aMann–Whitney test (two-tailed) was used for all genotype and sex specific comparisons
bStatistical differences between sexes within genotypes were not found, except for the histopathology score of ‘Femur bone marrow fatty infiltration’ among Ercc1 −/Δ7 mice; males: 2.8 (2.2–3.5) and females: 3.8 (3.1–4.6), p=0.0403. When analyzed by sex the histopathology score for ‘Femur bone marrow fatty infiltration’ was higher in both males (p=0.0060) and females (p=0.0211) in Ercc1 −/Δ7 mice compared to Ercc1 +/+ mice.