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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Ageing Res Rev. 2012 Apr 6;12(1):429–435. doi: 10.1016/j.arr.2012.03.012

Figure 3.

Figure 3

Antagonistic function of RNA editing in RNAi machinery: ADAR activity can modify target specificity of miRNAs or siRNAs, or transcripts of protein-coding genes. In addition, ADAR activity may prevent dsRNAs from entering the RNAi pathway by introducing RNA modifications (shown by red circles) that reduce the self-complementarity of the dsRNAs – a requirement for effective RNAi. This hypothesis is based on the observation that loss of RNA editing activity (RNAe) results in an accumulation of siRNA species and an increase in certain forms of RNAi-mediated gene silencing, but the silencing activity is suppressed by loss of an RNAi component.