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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Ageing Res Rev. 2012 Apr 6;12(1):429–435. doi: 10.1016/j.arr.2012.03.012

Figure 2.

Figure 2

A novel non-coding RNA role for tRNA-derived RNA fragments: A specific ribonuclease cleaves tRNA transcripts in response to stress (e.g. heat or oxidative stress), producing a nearly half-sized tRNA fragments (half-tRNAs). A subset of 5’ half-tRNAs cooperates with a translational silencer complex to inhibit translational initiation.