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5380390 and 2818500 do not inhibit SAM–dependent methyltransferases absent the SAM–binding cysteine. a) In vitro methylation of CARM1 on Histone3.1 after incubation with 10 and 100μM of potential inhibitors. b) In vitro methylation of Set7/9 on Histone3.1 after incubation with 10 and 100μM of potential inhibitors. c) In vitro methylation of PRMT8 on Histone4 after incubation with potential inhibitors. Data is representative of at least two independent experiments.
