Table 3.
Association between total serum testosterone and other potential confounders and risk of FibroSURE-ActiTest-determined advanced hepatic inflammatory activity (A2/A3 and A3) in male veterans with chronic hepatitis C infection.
| Characteristic | Univariate Models
|
Multivariate Model
|
||||
|---|---|---|---|---|---|---|
| Odds Ratio | 95% CI | p-value | Odds Ratio | 95% CI | p-value | |
|
|
|
|
||||
| Total Serum Testosterone Category^ | ||||||
| Highest (≥ 5.91 ng/ml) | 1.92 | (0.99–3.73) | 0.05 | 2.64 | (1.29–5.45) | 0.008 |
| Middle (4.12–5.90 ng/ml) | 2.03 | (1.02–4.04) | 0.04 | 2.67 | (1.28–5.54) | 0.009 |
| Lowest (≤ 4.11 ng/ml) | 1.00 (Ref) | - | 1.00 (Ref) | - | ||
| Diabetes Mellitus | ||||||
| Present | 2.35 | (1.33–4.14) | 0.003 | 2.65 | (1.45–4.86) | 0.002 |
| Absent | 1.00 (Ref) | - | 1.00 (Ref) | - | ||
| Age (years) | 0.99 | (0.94–1.04) | 0.64 | 0.99 | (0.94–1.04) | 0.74 |
| Race/Ethnicity | ||||||
| African-American | 1.51 | (0.92–2.48) | 0.11 | 1.65 | (0.97–2.81) | 0.07 |
| White +Other^^ | 1.00 (Ref) | - | 1.00 (Ref) | - | ||
| Viral Load (log 10 eq/ml) | 0.86 | (0.64–1.14) | 0.30 | 0.82 | (0.60–1.12) | 0.21 |
| Chronic Alcohol Abuse^^^ | ||||||
| Present | 1.10 | (0.65–1.84) | 0.73 | 1.11 | (0.64–1.91) | 0.72 |
| Absent | 1.00 (Ref) | - | 1.00 (Ref) | - | ||
| Overweight/Obese (BMI 25+) | ||||||
| Present | 1.26 | (0.73–2.20) | 0.41 | 1.29 | (0.71–2.34) | 0.41 |
| Absent | 1.00 (Ref) | - | 1.00 (Ref) | - | ||
^
Total serum testosterone categorized into tertiles using data from HCV+ veteran controls with neither advanced fibrosis nor advanced inflammation (N=175) to determine tertile cut-points.
^^
Whites (N=133) combined with Hispanic (N=14) and Other ethnicity (N=2).
^^^
Chronic alcohol abuse defined as present if veteran self-reported drinking ≥ 3 drinks/day for ≥10 consecutive years.