Table 4b. Effect of JNJ-10397049 (i.p.) on Sleep Parameters in Rats.
|
JNJ-10397049 |
|||
|---|---|---|---|
| Vehicle | 5 mg/kg | 25 mg/kg | |
| Awake (min) | 117.3±3.8 | 87.6±7.9* | 78.0±8.0* |
| NREM latency (min) | 40.1±7.3 | 27.2±4.2 | 24.1±5.2** |
| NREM sleep (min) | 54.9±3.5 | 85.4±7.4* | 90.1±19.6* |
| REM latency (min) | 75.0±9.7 | 58.0±7.7** | 52.3±10.2** |
| REM sleep (min) | 8.0±1.8 | 6.9±1.5 | 11.7±5.5 |
Data are the mean±SEM of eight animals for each experiment.
*P=0.001.
**P<0.05.