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. 2012 May 9;37(9):1999–2011. doi: 10.1038/npp.2012.48

Table 4a. Effect of SB-649868 (by Gavage) on Sleep Parameters in Rats.

  SB-649868
  Vehicle 3 mg/kg 10 mg/kg
Awake (min) 134±8.3 99.8±8.5* 65.5±3.5*
NREM latency (min) 46.1±10 19.0±2.2* 11.6±1.6*
NREM sleep (min) 43.9±8.0 74.2±8.5** 101.6±3.9*
REM latency (min) 146.3±5.4 30.1±6.3* 26.6±7.7*
REM sleep (min) 1.76±0.79 5.9±0.8** 12.7±1.5*

Data are the mean±SEM of eight animals for each experiment.

*P=0.001.

**P<0.05.