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| Compound | SB-649868 | JNJ-10397049 | GSK1059865 |
| Route | p.o. | i.p. | i.p. |
| Dose (mg/kg) | 3 | 10 | 10 |
| Tmax (h) | 1.0 | 5 | 0.5 |
| Cmax (ng/ml) | 333 (±52) | 14.2 (±1.0) | 366 (±70) |
| AUC 0–5 h (ng*h/ml) | 1260 (±262) | 64 (±4.3) | 1290 (±320) |
| Brain : blood ratio | 0.1 (±0.05) | 2.9 (±0.8) | 0.2 (±0.1) |
