Figure 4.
Daily saccharin preference in vehicle (n=8), 10 mg/kg PF-670462 (n=7), and 30 mg/kg PF-670462 (n=5) groups. Group-averaged daily preference taken for a period of 24 h averaged for the last 6 baseline days, the 2 last days of the treatment, and 4 last following days. The treatment differentially affected preference for the saccharin solution (FDay × Group(12, 102)=4.7, p<0.0001). During the posttreatment phase, 30 mg/kg PF-670462-treated rats showed decreased preference for saccharin as compared with vehicle-treated rats, as revealed by the significant post-hoc tests (p<0.05) for the days after treatment. Arrows indicate the administration of either vehicle or PF-670462. Data are presented as means+SEM. *Significant differences from the control vehicle group, p<0.05.