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Coronavirus genomes (A). The genome of four different coronaviruses is depicted. The open reading frame (ORF)1a/b is colored in red. The HE gene present in MHV-A59 is represented in purple. The gene of structural proteins S (blue), E (pink), M (dark pink) and N (cyan) are localized in the 3' part of the genome. ORFs encoding accessory proteins are represented in grey. Coronavirus virion structure (B).
