Figure 2. Mapping the 8p12 amplicon using high-resolution SNP arrays narrows its core to ZNF703. Copy number and expression mapping of the 8p12 distal amplicon for selected samples from the MB-series and sample NT-2347 from the NT-series.
ER status (determined by IHC), intrinsic subtype (using PAM50 classifier) are shown colour coded on the left. Colour bars on the right indicate log2 values. Top panel: IGV heatmap (http://www.broadinstitute.org/igv) of segmented copy number data for individual samples used to define the centromeric and telomeric boundaries of the amplicon. Bottom panel: Focused view of the two tumours in which the amplicon was restricted to ZNF703 illustrating probe-level copy number data (log2, black dots) and normalized expression values.