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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2012 Jan 19;32(3):669–676. doi: 10.1161/ATVBAHA.111.241836

Figure 2.

Figure 2

Attenuation by nicotinic acid (NA) (0.1 mmol/L) of induced cytokine release from human THP-1 monocytes in vitro, this effect is abolished with silencing of GPR109A (A–C) (n=4, *P<0.05, **P<0.01, ***P<0.001, Student t-test). Pretreatment of freshly isolated human monocytes with NA (0.1 mmol/L) or acipimox for 18 hours results in a reduction in lipopolysaccharide (LPS)-stimulated TNFα release (D) (n=3, *P<0.05). MCP-1 indicates monocyte chemoattractant protein 1; IL6, interleukin-6.