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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Mol Aspects Med. 2012 Apr 21;33(4):295–317. doi: 10.1016/j.mam.2012.04.005

Figure 5.

Figure 5

Schematic of a normal RPE/BrMb/CC complex (A) and the changes that occur in dry (B) and wet (C) AMD. (A) The CC (purple) lie under BrMb (Black line) and large choroidal blood vessels (blue/red) are below the CC. RPE reside on top of BrMb. In GA (B), RPE are lost and then the CC become attenuated but some CC survive but are constricted. In wet AMD (C), CC is lost while RPE remain. The RPE become hypoxic and produce hypoxia-inducible growth factors like VEGF, which stimulate the formation of CNV (solid purple blood vessel).