Figure 6.
Effect of CXCR2 blockade on peribronchial angiogenesis after allergen challenge. (A) Representative photomicrographs of immunostaining for von Willebrand factor of lung sections from alum- and OVA-challenged mice treated with isotype control or anti-CXCR2. (B) Bars represent mean ± SEM of vessels/mm2 immunostained for von Willebrand factor. (C, D) Total number of cells recovered from lung digests and bronchoalveolar lavage fluid, respectively. (E, F) Numbers of eosinophils (SiglecF-positive cells) and Th2 cells (CD3+CD4+T1ST2+ cells) in lung digests. (G) Bars represent mean ± SEM SDF-1α levels measured in lung tissue homogenates. * represents p < .05 compared to alum controls. ** represents p < .05 compared to OVA-isotype–treated mice. Data derived from 4-6 mice. Abbreviations: EPC, endothelial progenitor cell; OVA, ovalbumin; SDF-1α, stromal cell–derived factor-1α.