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Figure 2. Recruitment, proliferation and induction of Treg in the tumor microenvironment. (i) Recruitment of CCR4+ activated Treg by a CCL22 gradient produced by the tumor. (ii) Tumor expression of VEGF, IL-10 or TGFβ blocks DC maturation responsible for Treg induction and proliferation. (iii) TGFβ secreted by the tumor converts conventional CD4+T cells into regulatory T cells.
