. Author manuscript; available in PMC: 2013 Jun 4.

Published in final edited form as: Mol Pharm. 2012 May 14;9(6):1812–1821. doi: 10.1021/mp3001364

Table 1.

Average size and ζ potential of the dendrimer/siRNA dendriplexes.

Dendriplex	N/P ratio	PDI	Size (nm)	ζ potential
siRNA		0.396	241.9±48.1	−23.6±1.2
G5/siRNA	10/1	0.216	146.8±22.2^a	34.5±2.6
G6/siRNA	10/1	0.167	134.9±24.1^a	33.6±1.5
G5-PEG/siRNA	10/1	0.245	109.8±16.3^b	26.9±3.7
	20/1	0.236	102.9±30.8^b	30.7±3.6
G6-PEG/siRNA	10/1	0.193	129.4±12.0^b	27.9±2.8
	20/1	0.237	114.8±39.8^b	31.2±1.4

The dendriplexes were formed in 1 ml distilled water at various N/P ratios and the final concentration of siRNA was 2.4μg/ml.

p<0.05, compared with naked siRNA;

p<0.01, compared with naked siRNA.