Table 2.
Characteristics of Autopsied Participants by Clinical Pathological Groups, The 90+ Study
| Not Demented Insufficient Pathology (NDIP) | Demented Insufficient Pathology (DIP) | Demented AD Pathology (DAP) | NDIP vs DIP | DIP vs DAP | |
|---|---|---|---|---|---|
| p-value1 | |||||
| Clinical Diagnosis | 6 Normal 3 CIND |
5 AD 2 VaD 1 AD/VaD 1 Unknown |
9 AD 1 AD/VaD |
||
| Median (IQR) | |||||
| MMSE Score | 27 (24–28) | 17 (11–22) | 0 (0–4) | <0.01 | <0.01 |
| Age at death (years) | 96 (95–97) | 94 (93–96) | 95 (92–96) | >0.2 | >0.20 |
| Age at onset (years) | - | 90 (89–91) | 88 (84–92) | - | >0.20 |
| Age at diagnosis (years) | - | 92 (91–95) | 90 (87–93) | - | 0.08 |
| Diagnosis to death (years) | - | 2 (1–4) | 6 (4–9) | - | <0.01 |
| Brain weight (g) | 1199 (1169–1253) | 1086 (946–1192) | 1056 (982–1156) | 0.05 | >0.20 |
| Plaque stage | 2 (0–2) | 1 (1–2) | 2 (1–3) | >0.2 | 0.10 |
| Tangle stage | 3 (3–4) | 3 (2–3) | 6 (5–6) | 0.14 | <0.001 |
| Number (%) | |||||
| Female | 5 (56%) | 7 (78%) | 10 (100%) | >0.2 | >0.20 |
| Presence of APOE-e4 allele | 0 | 1 (14%) | 2 (25%) | >0.2 | >0.20 |
| History of TIA’s | 0 | 6 (67%) | 1 (14%) | 0.01 | 0.06 |
| Strokes in autopsy (single or multiple) | 6 (67%) | 2 (22%) | 2 (20%) | >0.2 | >0.2 |
CIND=Cognitive Impairment not demented; AD = Alzheimer’s disease; VaD=Vascular Dementia; AD/VaD = Mixed AD and Vascular Dementia; MMSE=Mini-Mental State Exam; TIA’s=Transient Ischemic Attacks; IQR = Interquartile Range; APOE = Apolipoprotein E
1
p-values are from Fisher’s exact test for proportions and from Wilcoxon Ranks Sum test for continuous variables