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Peripheral tolerance. T-cell anergy is induced by inhibiting mTOR pathways or can be induced by tolerogenic DCs. The expression of Egr2, Cblb, Ctla4, DgkZ, and Pdcd1 genes is important in T-cell anergy. Lymph node stromal cells (LNSCs) express tissue-specific antigens (TSAs) and can mediate the deletion of self-reactive naive T cells.
