Fig. 1.
Ontogeny of liver transporters: sodium taurocholate cotransporting polypeptide (Ntcp; basolateral uptake), organic solute transporter (Ost)α, Ostβ, multidrug resistance-associated protein 4 (Mrp4; basolateral efflux), bile salt export pump (Bsep), and multidrug resistance protein 2 (Mdr2; canalicular efflux) in wild-type mice from 2 days before birth to 45 days of age. Total RNA was isolated from liver at each age and analyzed by the bDNA assay as described in materials and methods. Data are presented as mean relative light units (RLU) ± SE (n = 5 animals). *Significant differences (P < 0.05) compared with values at 45 days of age.