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. Author manuscript; available in PMC: 2013 May 25.
Published in final edited form as: Immunity. 2012 May 10;36(5):717–730. doi: 10.1016/j.immuni.2012.03.020

Figure 1.

Figure 1

Foxp3gfp NOD mice develop accelerated autoimmune diabetes. (A) Female Foxp3gfp (n=29), Foxp3gfp/wt HET (n=19) and WT (n=25) NOD mice in the same colony were monitored weekly for diabetes onset (***p<0.001, **p<0.003; Kalpan-Meier with groups compared using the Log-rank test). (B) Insulitis scoring of Foxp3gfp and WT NOD mice was performed at 8 weeks of age. (C) Cellular infiltrate in the islets, PLN, and spleen of 8 week old pre-diabetic WT, Foxp3gfp and FoxP3GFP-hCre NOD mice were analyzed by flow cytometry (n=6–10 mice per group; *p<0.05, **p<0.01, ***p<0.001). Error bars represent SEM.