Fig. 1.
Chromosome 8p deletion characteristics and co-occurring genomic aberrations. (A) Size and extent of chromosome 8p deletions (in blue) and amplifications (in red) from individual HCCs, breast cancers, colon cancers, and lung adenocarcinomas based on aCGH data analysis (Materials and Methods). The 8p22 cytoband is highlighted by a dashed line, with the organization of the 8p22 genes indicated on the right. (B) Chromosome 8p deletions co-occur with genomic aberrations in HCC, including amplifications (red) of 1q, 5p, 6p, and 8q and deletions (blue) of 17p. Fisher’s exact test was used for statistical calculations. (C) Unsupervised hierarchical clustering of genomic aberrations indicates 12 groups within the HCC dataset (n = 197). Occurrence of 8p deletion (dark red), 8q amplification (dark blue), and 17p deletion (dark orange) within the individual samples is highlighted below the dendrogram.