Figure 6.
Interstitial fibrosis and the expression of collagens and hypertrophy markers in Thbs4−/− mice 2 wk after TAC. A) Fibrosis in sham-and TAC-operated mice, percentage fibrosis of the tissue section (total area=100%); n = 5. B) Fibrosis in nonoperated 80-wk-old mice, percentage fibrosis of the tissue section (total area=100%); n = 5. C) Expression of mRNA of hypertrophy markers and collagens in hearts of TAC-operated mice. D) Expression of collagen II mRNA. Shaded bars, WT mice; solid bars, Thbs4−/− mice. Values are means ± se.