Skip to main content
. 2012 Jun;235(2):528–538. doi: 10.1016/j.expneurol.2012.02.017

Table 3.

Effect of GW9662 treatment on striatal dopamine and DOPAC levels. No difference is seen in MPTP induced reductions in dopamine and DOPAC levels between mice treated with GW9662 (5 mg/kg daily) or those receiving vehicle (5% DMSO — see text for details). Data are mean ± SEM, n = 4–5 mice per group. *p < 0.05, **p < 0.01, ***p < 0.001 compared to appropriate saline treated group (Kruskal–Wallis test with Mann Whitney U-post hoc tests).

Saline
MPTP
Vehicle GW9662 Vehicle GW9662
Dopamine (ng/mg wet tissue) 11.81 ± 1.80 14.01 ± 1.40 1.13 ± 0.30* 1.00 ± 0.45***
DOPAC (ng/mg wet tissue) 1.62 ± 0.38 1.41 ± 0.22 0.25 ± 0.10** 0.22 ± 0.04***