Fig. 13.
Comparison of firing patterns in model and human thalamic neurons. A: mean normalized autopower computed for tremor-related neurons in human thalamus during postural tremor exhibits a strong peak at ∼5 Hz (Hua and Lenz 2005). B: mean normalized autopower computed for the population of 50 model neurons shows a similar peak at ∼5 Hz. Normalized autopower was averaged across all 50 neurons during the time period from 2 to 12 s with stimulation off. C: preburst ISIs in the Vim and Vc thalamus in subjects with ET (Ohara et al. 2007) along with the preburst ISIs of the model Vim neurons. The human Vc data are shown to demonstrate that the internuclear difference is much larger than the difference between the model and human Vim. Model preburst ISI estimates were made by combining all averaged across the 25 bursting neurons during the same time period (means ± SE = 173 ± 2 ms). D: poststimulus inhibition seen after 0.5 s of stimulation at 200 Hz observed in human thalamus (top; Dostrovsky and Lozano 2002) and in the model Vim neuron (bottom). Time scale bar applies to both traces. Vm (20 mV) scale bar applies only to the bottom trace, as the top trace is an extracellular recording. Thick gray bar represents stimulation on in both the human and model.