Table 4.
Flavopiridol pharmacokinetics by dose level during cycle 1.
| Cohort | Doxo | Flavo | n | Mean Cmax (uM) | Standard Deviation (SD) |
|---|---|---|---|---|---|
| 1 | 60 | 40 | 3 | 2.27 | 0.49 |
| 2 | 60 | 50 | 3 | 2.23 | 0.52 |
| 3 | 60 | 60 | 3 | 3.29 | 1.39 |
| 4 | 60 | 70 | 3 | 2.22 | 0.07 |
| 5 | 75 | 60 | 3 | 2.46 | 0.67 |
| 6 | 60 | 70 (40/30) | 4 | 2.56 | 0.31 |
| 7 | 60 | 80 (50/30) | 6 | 3.03 | 1.29 |
| 8 | 60 | 90 (50/40) | 4 | 3.33 | 1.38 |