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. 2012 Mar 22;287(18):14615–14620. doi: 10.1074/jbc.C112.353946

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — NADP⁺, ICT, and 2HG regulation of IDH1 and IDH1(R132H). A, NADP⁺ inhibition of NADPH oxidation by IDH1(R132H) homodimers (R132H/R132H; ○) and IDH1^WT/R132H heterodimers (WT/R132H; ■). B, ICT regulation of NADPH oxidation by IDH1(R132H) homodimers (○) and IDH1^WT/R132H heterodimers (■). C, 2HG inhibition of NADPH oxidation by IDH1 homodimers (WT/WT; ●), IDH1(R132H) homodimers (○), and IDH1^WT/R132H heterodimers (■). The spectrofluorometric assay following αKG-dependent NADPH oxidation was used in these experiments. Means ± S.E. of triplicate measurements are plotted.